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Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

Knowles L, Morris AA, Walter JH (2016) Treatment with mefolinate (5-methyltetrahydrofolate), but not folic acid or folinic acid, leads to measurable 5-methyltetrahydrofolate in cerebrospinal fluid in methylenetetrahydrofolate reductase deficiency

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also pointed out that baseline elevated Hcy among untreated de novo PwPD was associated with lower baseline MMSE as well as greater cognitive decline during diseases progression (Christine et al