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This may be because nicotine increases inflammation in the body, because smoking affects how the body metabolizes treatment medications, or a combination of both

Biomed Pharmacother 2003

Hasbaoui BE, Mebrouk N, Saghir S, Yajouri AE, Abilkassem R, Agadr A

Tardive Dyskinesia A syndrome of potentially irreversible, involuntary, dyskinetic movements may develop in patients treated with antipsychotic drugs

H., Kang, P

CpG-ODNs activate plasmacytoid dendritic cells and B cells via the TLR9MyD88NF-B pathway, inducing CD80/CD86 expression and cytokine secretion (e.g., type I interferons, IL-12), which enhance T-cell priming and systemic antitumor immunity