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The senescence-associated secretory phenotype (Sasp) in the challenging future of cancer therapy and age-related diseases

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For instance, the observed downregulation of ADRB2 could potentially influence lipolysis via the G inhibitory protein (Gi)-cAMP-Phosphodiesterase 4 (PDE4) axis 63 , and modulate BCL3 trafficking through Beta-Arrestin 2 (-arrestin2)/Extracellular Signal-regulated Kinase (ERK) signaling 64

Gnerre, S

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However, the persistent activation of DNMT1 led to hypermethylation of the POLG1 promoter in the retinal endothelial cells (RECs) that were exposed to normal glucose following exposure to high glucose