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[DOI] [PMC free article] [PubMed] [Google Scholar] 85.Jacobi N., Herich L

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TNF- can activate the apoptotic signaling pathway by targeting TNFR1 or activate downstream NF-B to induce the production of other cytokines by targeting TNFR2 (Sun and Kanwar, 2015)

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However, anti-inflammatory therapies so far failed to consistently ameliorate obesity-associated diseases in humans 67