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Description

J Integr Oncol 6:194

In sepsis-induced AKI models, PKM2 inhibition attenuates the activation of NLR family pyrin domain containing 3 (NLRP3) and absent in melanoma 2 (AIM2) inflammasomes, decreases the release of IL-1, IL-18, and HMGB1 by macrophages, and ultimately improves survival outcomes (Xie et al., 2016)

The modified liposomes also supported sustained release profiles, establishing the potential for applications in functional foods and pharmaceuticals [66]