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The caudal approach may be less effective but is considered safer and easier to perform

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This is supported by the finding of a reduced percentage of Tie2 + cells in elderly NP cells compared to young cells, while GD2 expression is maintained with age

doi: 10.1001/archneur.55.11.1449

In an ongoing phase 1/2 trial (NCT04786262) involving patients with severe T1D, the first treated individual showed detectable endogenous insulin production (measured by C-peptide) and a 91% reduction in exogenous insulin requirement 90 days after infusion of SC-beta cells (stem cellderived, insulin-producing pancreatic cells) [111]

A research use only label does not authorize a product to be marketed as a drug or exempt a seller from Canadian regulatory requirements