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doi: 10.1016/j.fct.2014.11.006

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Therefore, bi-directional causal effects were observed, and instances of true bi-directional pathway might exist, and in other words, a proposed positive effect of vitamin B12 on NAFLD risk, whereas NAFLD also exerts a positive effect on vitamin B12, possibly as part of a positive feedback loop

Endothelial nitric oxide synthase (eNOS) is the major enzyme responsible for NO production in blood vessels and regulation of vascular permeability [34, 35]

First, its helpful to understand the RDA system

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