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10.1146/annurev.neuro.31.060407.125646 9 BourneJ

Whether thats a dose issue, a formulation issue, the difficulty of controlling for diet and exercise, or a ceiling on what this mechanism can actually achieve in humans is still somewhat open

Extremely high or low pH values generally result in complete loss of activity for most enzymes

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Human Gut Microbial Diversity: Clinical Evidence Supporting Simultaneous Use of Antibiotics and Probiotics A Coachrane review of 23 studies assessing the efficacy and safety of probiotics for the prevention of pediatric antibiotic-associated diarrhea A systematic review and meta-analysis of 23 randomized controlled trials with nearly 4,000 participants found that the incidence of pediatric antibiotic-associated diarrhea was 8% in children taking antibiotics with probiotics compared to 19% in children who didnt take probiotics with antibiotics