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Challenges remain due to complex mitral anatomy, proximity to LV outflow tract, valve positioning, mitral annular calcification, large delivery systems and valve size, device thrombosis, and hemolysis in addition to complications from transapical access

Gently swirl the vial in circular motions until fully dissolved

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Divide your target dose in micrograms (mcg) by the vial concentration in mg/mL, then multiply by 1000 to convert to microliters (mcL) or syringe units