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Importantly, carnosine was consistently downregulated in both pneumonia models as it is mechanistically linked to histidine and thiamine metabolism (Figures 2F, G), which suggests that carnosine may serve as a critical pneumonia-associated metabolite

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Studies will be needed to determine the appropriate metformin dose for use in NAFLD therapy

Approximately 50 mg of tissue was collected for determination of GSH content, as previously described

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Obesity, Diabetes, and Leptin Resistance Promote Tau Pathology in a Mouse Model of Disease