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CrossRef Efficacy and safety of adding a fourth oral antidiabetic drug versus metformin dose escalation in patients with type 2 diabetes inadequately controlled on triple oral combination therapy (EFFORT): A 24week, randomized, openlabel, multicenter trial So Ra Kim, Jun Hwa Hong, Sin Gon Kim, SooKyung Kim, HyukSang Kwon, Jun Sung Moon, Jung Hwan Park, Jae Myung Yu, BongSoo Cha, ByungWan Lee Diabetes, Obesity and Metabolism.2026

In response to oxidative stress, high levels of H 2 O 2 promote Cu/Zn SOD nuclear translocation and as a transcription factor the enzyme regulates the expression of oxidative resistance and repair genes (44)

NBS-induced colitis: Another acute inflammatory model more resemble to Crohn's disease, with mixed innate and adaptive immune responses ( 97 )

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Regulation of intestinal flora Oral ingestion is the most convenient route for herbal medicine utilization, but first-pass metabolism in the liver and intestine adversely affects the effective conversion of active herbal ingredients

They sleep with the goats and stand over them guarding them, especially the babies