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Further biochemical studies have shown increased levels of neuroketals in the SNc in post mortem tissue from Braak stages 1 and 2, supporting the notion that oxidative damage to specific lipids in the SNc occurs at very early stages of PD and prior to the appearance of LBP [83, 84]

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RNA extraction and quantitative real-time PCR (qRT-PCR) RNA was extracted from the cochlea using an RNA Express purification kit (#RN001, Yeasen, China) according to the manufacturers instructions

The aromatic by-products produced during fermentation can vary drastically, depending on the starting material (fruit, grain, or extract), the concentrations of carbon and nitrogen, and the yeast strain used (Henschke and Jiranek 1993, Verstrepen et al