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Antioxid Redox Signal 23(3):208238 Givler D, Givler A, Luther PM, Wenger DM, Ahmadzadeh S, Shekoohi S, Edinoff AN, Dorius BK, Jean Baptiste C, Cornett EM (2023) Chronic administration of melatonin: physiological and clinical considerations

Its molecular formula is C152H252N44O42 with an average molecular weight of approximately 3367.9 g/mol, and its full sequence is Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Gln-Ala-His-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Gln-Ala-His-Asn-Ser-Tyr-Arg-Lys-Leu-Leu

To improve biosafety, researchers have developed a series of stable prodrugs preferentially released DON in the tumor microenvironment (Lemberg et al., 2018