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Shishko PI, Dreval AV, Abugova IA, Zajarny IU, Goncharov VC

Prior to treatment, [ 89 Zr]Zr-DFO-daratumumab could serve as a predictor for the tumor's response to daratumumab therapy, and as biomarker for monitoring the response to daratumumab therapy [65]

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Study endpoints include epithelial-barrier function, tight-junction protein expression, inflammatory signaling, and mucosal tissue remodeling in models of intestinal inflammation, increased permeability, and chemically induced gastrointestinal injury