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The naturally occurring endocannabinoid anandamide also caused similar 24 h loss of cell viability in developing mouse cortical neurons at concentrations ranging from 1 to 100 mcg/mL, indicating the mechanism of cell death could be mediated through the cannabinoid receptors

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As mentioned previously, cysteine is critical in the production of glutathione

Carbon monoxide (CO), a major metabolite of HO-1, has been reported to stabilize the HIF-1 protein via translational suppression of HIF-1 ubiquitination 61,62