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So T, Ishii N

Koglin, M

The last enzyme in the pathway is not found in cardiac or skeletal muscle (17)

Patients with chronic kidney disease, congestive heart failure, or a history of alcohol consumption, severe dehydration, shock, hypoxia, sepsis, or advanced age face a heightened risk of biguanide-associated lactic acidosis [72]

[DOI] [PMC free article] [PubMed] [Google Scholar] 164.Ke J., Tian Q., Xu Q., Fu Z., Fu Q

doi: 10.3389/fnut.2025.1754492 Received 26 November 2025 Revised 20 December 2025 Accepted 24 December 2025 Published 21 January 2026 Volume 12 - 2025 Edited by Javier Diaz-Castro, University of Granada, Spain Reviewed by Mahsa Rezazadegan, Isfahan University of Medical Sciences, Iran Soroush Taherkhani, Iran University of Medical Sciences, Iran Updates Copyright 2026 Poon, Li, Schweitzer and Akefe