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As anticipated, EVs derived from VDAC1-deficient cells exhibited markedly reduced VDAC1 and P-gp levels compared to control EVs ( Figure 3C ), suggesting a critical association between EV-derived VDAC1 protein and chemoresistance acquisition

Excitingly, we also identified two benzaldehyde-based NSD2 degraders, UNC10415667 and UNC12149, that are equally effective in cells as our previously reported prodrug degrader, UNC8732

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Rhonda Patrick: So, it really does hammer home the importance of measuring your vitamin D levels and being very proactive about that

Compounds targeting body recomposition (like growth hormone secretagogues) benefit from IM because rapid systemic distribution is the goal