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Research has shown that neuromelanin increases oxidative stress, as marked by elevated levels of reactive oxygen and nitrogen species in isolated mitochondria from SH-SY5Y cells

However, for HGGs despite having a multimodal treatment approach encompassing surgery, radiation therapy, and chemotherapy, yield only partial and transient responses

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Furthermore, a retrospective study on 30 patients of mean age of 13.93 years (12 - 17) with isolated meniscal tear showed a significant improvement of knee symptoms and daily activity according to Lysholm score 3 months after the PRP injection: from 3% of the patients having a good score to 76.7% of the patients having excellent and good outcomes after treatment 13

0.3% control (all p 1 year follow up

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