glutathione degradation human Is a Key Determinant of Glutathione Homeostasis Glutathione Degradation - Anand Kumar

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Des tudes animales et humaines dmontrent quune nutrition adquate en protines est cruciale pour le maintien de lhomostasie de la GSH]..[La carence en glutathion contribue au stress oxydatif, qui joue un rle cl dans le vieillissement et la pathogense de nombreuses maladies (y compris le kwashiorkor, les convulsions, la maladie dAlzheimer, la maladie de Parkinson, la maladie du foie, la fibrose kystique, etc, anmie falciforme, VIH, SIDA, cancer, crise cardiaque, accident vasculaire crbral et diabte)

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Phase-II Drug Metabolism Most of the time gives metabolite that is: More polar Non-toxic Pharmacologically inactive X = O, N, S Phenol, alcohol and carboxylic acid Amine (aliphatic and aromatic) Thiol Sometimes: Phase-II gives: Less polar conjugate: Methylated drug Acetylated drug Toxic metabolite: Some sulfate conjugates Some Acetylated metabolites