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There is a relationship between increasing hydrocodone plasma concentration and increasing frequency of dose-related opioid adverse reactions such as nausea, vomiting, CNS effects, and respiratory depression

In rats, intravitreal injection of TNF- correlates with optic nerve degeneration and delayed death of retinal neuronal cells, associated with increased expression of NF-B p65 in the optic nerve, suggesting a link to TNF--induced axonal degeneration (165)

Challenges in the identification of cobalamin deficiency polyneuropathy

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