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While Apta1 and Apta2 were ultimately selected with high enrichment, it is noteworthy that their binding affinity is low

Cao DP, Zheng YN, Qin LP, Han T, Zhang H, Rahman K, et al

Cellular uptake was evaluated in SH-SY5Y neuroblastoma and hBMECs using confocal laser scanning microscopy and flow cytometry revealing 5.4X higher uptake of lactoferrin-conjugated nanoparticles as compared to non-conjugated PLGA NPs following 5 h of exposure

Huang Y, Dai Z, Barbacioru C, Sade W

These are broad effects and for many, concentrations of only a few millimolar are sufficient, so well below the concentrations found in the cytosol even in K-starved cells

The same riboflavin-overproducing strain also showed antioxidant and anti-inflammatory mechanisms by attenuating motor deficits and prevented dopaminergic neuronal death in murine models of Parkinsons disease 204