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This dual role of lactate in modulating ferroptosis and inflammation may account for the inconsistent therapeutic outcomes associated with hypertonic sodium lactate administration in sepsis, as these effects appear to be highly dependent on factors such as timing of intervention, dosage and the specific experimental animal models employed (104,109)

Na 25 stepeni, slabo je rastvorljiv u vodi, sa rastvorljivou od priblino 100 mg/mL (70,44 mM)

ROS, such as superoxide (O 2 - ), can be produced in mitochondrial complexes I and III in components of the tricarboxylic-acid cycle, including -ketoglutarate dehydrogenase (EC 1.2.4.2), and in the outter mitochondrial membrane, damaging cell components such as lipids, proteins and DNA [25, 47]

it is the most common genital disorder identified at birth [24, 25]

Nature 431 , 931945 (2004)

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