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Statements Author contributions DX, YL designed the study together, equal contribution, Listed as co-first author

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The science supporting sublingual delivery has advanced dramatically, with novel formulations now achieving bioavailability levels that rival subcutaneous injection in certain peptide categories

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25 A subsequent single-center placebo-controlled, multiple-ascending dose, phase 1b trial examined the safety, tolerability, pharmacokinetics, and pharmacodynamics of cagrilintide in combination with semaglutide