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However, increasing non-ionic surfactants and cholesterol beyond optimal levels (above 30 mg) led to reduced entrapment efficiency and larger particle sizes in niosomes, likely due to disrupted vesicular structures and potential formation of mixed micelles 56,57

However, less appreciated is that pre-diabetes subclinical elevations in blood sugar may also cause RLS while remaining under the diagnostic radar of most physicians (Gemignani 2007

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Funding This research was funded by the Opening Fund of the Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Chengdu University (No

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