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Clinical research showed measurable increases in blood glutathione levels within one month, with continued improvement at three and six months

doi:10.1016/j.bbr.2009.07.020, PMID: 19643148 Kumar A, Garg R (2009) Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations

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Nonetheless, some limitations should be noted

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[1] These are meaningful cosmetic endpoints, and they map logically onto the mechanism: more collagen and glycosaminoglycan synthesis, better-organized remodeling, and reduced oxidative and inflammatory burden should, in principle, translate into firmer, smoother, more resilient skin