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Chronic pain involves persistent nociceptor and microglial overactivation, which leads to electron transport chain (ETC) dysfunction in neuronal mitochondria and excessive production of reactive oxygen species (ROS) and reactive nitrogen species (RNS)

Larazotide (Alba Therapeutics, Baltimore, MD) is being tested in a randomized, placebo- controlled trial

It is currently the most effective single-agent weight loss peptide available

Growth hormone-releasing peptides, including Ipamorelin and CJC-1295, offer a different but complementary approach to surgical recovery enhancement

Agricultural and Food Chemistry , 58 (8),4731-4736

Other autophagy enhancers, such as spermidine, also indirectly diminish mtDNA release by promoting the clearance of defective mitochondria [195]