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Historically, DBS targets have been identified pre-surgically on structural MRI scans in standard stereotactic anatomical space based on atlases [91, 92], which fails to consider individual variability of gray matter morphology or white matter fibers

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Splenectomized 4.2 / mice treated with mitapivat had significant reductions in Vcam1, Icam1, and Tbx expression in isolated aorta compared with splenectomized 4.2 / mice (Figure 6F and Supplemental Figure 10C)