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Ai-Ping Wang for critical reading of the manuscript and Editage (www.editage.cn) for English language editing

In fatty acid synthesis, biotin is required by the enzyme that forms malonyl CoA from acetyl-CoA, as shown below1

265,266 Disorders of metabolic homeostasis in obese individuals promote several pathological processes, such as type 2 diabetes, insulin resistance, and an increased incidence of various cancers

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Viswanathan VS, Ryan MJ, Dhruv HD, et al

5.4 Experimental validation of epigenetic mechanisms Recent technological advances in genome editing and single-cell analysis have provided powerful tools to validate EED-induced epigenetic modifications as causal mechanisms underlying transgenerational reproductive toxicity