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Reclast is contraindicated in patients with creatinine clearance less than 35 mL/min and in those with evidence of acute renal impairment due to an increased risk of renal failure [see Contraindications (4), Warnings and Precautions (5.3), Use in Specific Populations (8.6)]

In both mice and rhesus macaques, a two-dose intramuscular immunization regimen resulted in durable, robust, and broad neutralization against all SARS-CoV-2 variants tested, including the Omicron subvariants BA.4/539 and BQ.140

PLoS One 13(5):e0196436