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This is particularly relevant for conditions where the line between allergy and autoimmunity blurs, such as eosinophilic esophagitis or chronic urticaria with autoimmune features

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Although, DNA hypomethylation, hypermethylation, and down regulation of tumor suppressor genes (TSGs) have been recognized as a major factor for HNSCC progression

(For more information on titrations and the equivalence point, see Chapter 4 "Reactions in Aqueous Solution", Section 4.9 "Quantitative Analysis Using Titrations".) For the titration of a monoprotic strong acid (HCl) with a monobasic strong base (NaOH), we can calculate the volume of base needed to reach the equivalence point from the following relationship: Equation 16.50 If 0.20 M NaOH is added to 50.0 mL of a 0.10 M solution of HCl, we solve for V b : Figure 16.18 The Titration of (a) a Strong Acid with a Strong Base and (b) a Strong Base with a Strong Acid (a) As 0.20 M NaOH is slowly added to 50.0 mL of 0.10 M HCl, the pH increases slowly at first, then increases very rapidly as the equivalence point is approached, and finally increases slowly once more