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Pancreatitis seen in up to 7% of adults within the first few weeks of treatment necessitates azathioprine discontinuation [142]

Epidemiological studies indicate that VaD accounts for 1520% of dementia cases in Europe and the United States, and up to 30% in developing countries, placing a significant medical and economic burden on societies and families (Wolters and Ikram, 2019)

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These effects are mediated through interactions with neural proteins, although these findings are presently confined to animal-based research

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Finally, T-BPH rat model was treated with GPX3 indirect agonist troglitazone (TRO) or GPX4 inhibitor RAS-selective lethal 3 (RSL3) or TRO plus RSL3