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Dynamic changes in p O 2 , therefore, constitute a potential signaling mechanism for the regulation of the expression and activation of redox-sensitive transcription factors, apoptosis signaling and proinflammatory cytokines [13, 14, 1618]

In addition, protein kinase-C translocation from cytosol to the plasma membrane, vitally necessary for T cell migration and immunological synapse, is reduced in the iron deficient state (125, 126)

Costantini A, Pala MI, Compagnoni L, Colangeli M (2013) High-dose thiamine as initial treatment for Parkinsons disease