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This oxidative stress damages mitochondrial DNA and surrounding cellular structures, further impairing energy output

mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity

Moreover, hierarchical clustering of the RNA-seq data revealed that samples grouped primarily according to their TOX condition, indicating a high degree of similarity in their global gene expression profiles and suggesting that the physiological condition is a major determinant of transcriptomic variation in our dataset (Figures 9C, 10B)

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The benefits were specific and bounded: sleep architecture, recovery, and gradual body composition, rather than a broad transformation

We find that both increasing age and microbial depletion sensitize Drosophila to acetaminophen toxicity