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The activation of BK Ca channels by H 2 S is mediated via TRPV4 channels and subsequent Ca 2+ influx ( 2 S-producing enzymes CBS and CTH increases in the epididymis from the caput to the cauda epididymis, corresponding to the increasing production of endogenous H 2 S ( + concentration in rat intraluminal fluid also increases from the caput to the cauda, which supports the idea that H 2 S increases K + secretion (112)

37 Notably, aging immune cells exhibit impaired secretion of type I interferons (IFN-I), which are downstream effector molecules of cGAS-STING signaling

Funding This study was supported by grants from the National Natural Science Foundation of China (NO

In the context of GBM, reducing iron levels may potentially decrease ferroptosis, rendering GBM cells more resistant to therapies that induce this form of cell death

10.1038/s41565-024-01851-7 109 LiuJ.LiuC.ZhangJ.ZhangY.LiuK.SongJ

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