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Se supplementation increases SELENOS expression, alleviates ER stress, and suppresses Tau hyperphosphorylation, delaying NFT formation (Rueli et al., 2017)

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Conclusion In this review, we have discussed the biological traits of GBM and the BBB that pose challenges for the development of current therapeutic agents with an emphasis on novel drugs and alternative methods of drug delivery, and the ongoing challenges of drug design, positing combination therapy and novel trial designs with early integration of on-treatment tumor tissue analysis and imaging biomarkers as optimal strategies for early trial designs moving forward

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