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R.ZengN.CadenasE.et al (2013)

(PubMed) Olson AL, Nelson SE, Rebouche CJ

Furthermore, K447 is located in the Ubiquitin C-terminal Hydrolase (UCH) domain of USP2, which is the core catalytic region of USP2

However, as the disease progresses, patients will gradually experience symptoms such as decreased vision, blurred vision, glare, strabismus, diplopia, and reduced contrast sensitivity, which seriously interferes with patient's daily activities and has a great impact on their quality of life (70)

Additionally, melatonin secretion patterns in NS workers were associated with differential methylation of key circadian genes, including RORA, MTNR1A, and PER3, suggesting a potential link between circadian disruption, epigenetic regulation, and cancer risk 196