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Tamoxifen was prepared fresh on the day of administration by diluting it with corn oil (Sigma-Aldrich) to a concentration of 40 mg/ml as previously outlined (McKenzie et al., 2014)

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We further classified the trials into two subgroups (liberal and conservative) depending on the stopping rule in the PCT group except for three trials [39, 51, 52] that used a very unique protocol and studies using only starting rules that did not report this outcome [41, 46, 49]

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