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When administered under licensed medical supervision using pharmaceutical-grade compounds, the combination has a well-documented safety profile

Whilst certain studies do hint at possible direct effects of thiazide, thiazide-like and loop diuretics on glucose homeostasis, and that its control is apparently beneficial for some aspects of the MetS, it is clear that additional research is necessary to fully understand the specific mechanisms involved and the potential clinical implications that they may have in hypertensive individuals with chronic metabolic conditions

10.3892/ijmm.2013.1462 260 XuW.ChenJ.LinJ.LiuD.MoL.PanW.et al (2015)

The lungs were removed and embedded in paraffin after fixing by 4% paraformaldehyde

3.1.1 Mode of action The activation of a transcription factor, peroxisome proliferator-activated receptor (PPAR), is the mechanism by which TZDs exert their anti-diabetic action