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Melanotan-II (MT-II), a synthetic peptide known to mimic alpha-melanocyte-stimulating hormone (-MSH) and act as a melanocortin receptor 4 (MC4R) agonist, was the central therapeutic agent explored

Some of these, such as genetics, are out of the persons control

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Felicia Morris Institution: Stanford Neuroscience Institute, USA Result: NSC transplantation in murine models of insomnia regenerated inhibitory neurons in the ventrolateral preoptic nucleus (VLPO), a sleep-promoting region

Gaps: dosing, delivery, safety, and large RCTs remain

A later systematic review of 11 studies also found benefit from electroacupuncture, though results were inconsistent