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Despite that treatment with HeA increased ERK44/42 phosphorylation in PC-12 cells to enhance NGF-induced neurite outgrowth 14 , we found that exposure of OLs to HeA for 3 days had no effect on the levels of pERK44/42 phosphorylation in OLs (Fig

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Identification of a nuclear receptor that is activated by farnesol metabolites

Various factors are involved in the progression of DN, such as disorder of oxygen metabolism and lipid metabolism, hyperglycemia, advanced glycosylation products, and inflammatory response [140, 141]

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