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The A53T transgenic mouse model effectively reflects the pathological manifestations of -syn, demonstrating significant neurodegeneration, deterioration of motor function, and non-motor symptoms (Taguchi et al., 2020)

Although pharmacological efficacy of some drugs was claimed to be improved after administration of developed derivatives compared to parent drug dosing, in these studies, the derivatives as such were either shown to be active or their activity has not been investigated

p53 Recent studies suggest that p53 plays an important role in controlling metabolism and ferroptosis and that p53 in normal cells can negatively regulate lipid synthesis and glycolysis and positively regulates oxidative phosphorylation and lipid catabolism

In in-vivo studies using the IMQ-induced PsO model, treatment with the NLC-based ointment significantly reduced the spleen index and levels of TNF-, IL-6, and IL-17

With the correct vitamin B12 dosage, the daily requirement can be covered and the body stores sufficiently topped up

It does not have to be converted but also has a shorter shelf life and may be pricier than others