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Gene set enrichment analysis (GSEA) was performed using the fgsea R package (version 1.29.1) 36

Preclinical studies in HeLa cell models support nuclear membrane permeation and DNA interaction, with observed reductions in reactive oxygen species accumulation and caspase-3 activity in hypoxic and ischemic stroke models

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In addition, some researchers have used immunotherapy and synthetic biology to design living bacteria, combining immunotherapy expression with optimized lysis mechanism, so that living bacteria can carry nanobodies back to the core of necrotic tumors, grow to a critical density, and lyse, effectively and continuously releasing therapeutic drugs in the tumor microenvironment

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