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128 Disruption of gut barrier integrity and microbial translocation: The accelerator of liver disease progression Pathophysiological changes in gut barrier structure and function As a key physical and immunological defense line separating intestinal lumen contents from the hosts internal environment, the integrity of the gut barrier suffers systemic destruction during the progression of liver diseases

The Centre has conducted studies in collaboration with several companies including GSK, Pfizer, Wyeth and Mead Johnson

Cellular hierarchy and therapy resistance in CSCs The hierarchical model of tumour organisation places CSCs at the apex, with progenitor-like cells and differentiated tumour cells arising from this sub-population [69]

Ethics statement The studies involving humans were approved by Ethics Committee of the Area Vasta Nord Ovest Toscana (Italy)

This will reduce run times

Figure 9A illustrates the operational principle of this aptasensor, where the binding between insulin and aptamers is detected via EIS