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This segment's dominance is further strengthened by the growing desire for quicker and more precise decision-making

Interestingly, while the role of GSTs has classically been associated to the modification of small molecules and the role of glutaredoxins to the deglutathionylation of proteins, it has recently been shown that human GSTO1-1 can deglutathionylate -actin, which should prompt us to consider proteins as GST substrates (Menon and Board, 2013)

The FLAMENCO project

10.1158/0008-5472.CAN-23-1148 146 SchlaepferI

TMA can be catalyzed as TMAO by flavin mono-oxygenase 3 (FMO3), a key rate-limiting enzyme in the liver

One common approach involves using high concentrations of denaturing agents such as urea followed by dilution and digestion