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Collectively, these counterbalancing measures act to elevate iron availability, while simultaneously blunting global protein translation and activating a distinct transcriptional stress response program

Pharmacol., 35, 4153-4159

In this respect, SetCys uncovers an unusual mode of reactivity for Cys and provides a useful means for accessing complex protein scaffolds as illustrated by the total one-pot synthesis of biologically active backbone-cyclized variants of the hepatocyte growth factor (HGF) kringle 1 (K1) domain