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R-phenylisopropyladenosine attenuates noise-induced hearing loss in the chinchilla

Ristow, Mp

Supplementary material The Supplementary Material for this article can be found online at: Abbreviations ABR auditory brainstem response AG aminoglycosides ANOVA analysis of variance ASR acoustic startle reflex CF cystic fibrosis CMD center of mass displacement DMSO dimethylsulfoxide GAP trial with gap preceding startle SO trial with startle only GPIAS gap-induced prepulse inhibition of the acoustic startle reflex IHC inner hair cell IO input/output kHz kilohertz LDL loudness discomfort level OHC outer hair cell SGN spiral ganglion neurons TB tuberculosis

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Indeed, treatment of buthionine sulfoximine (BSO), a specific inhibitor of GSH synthesis, depleted intracellular GSH levels but did not prevent extracellular GSH from rescuing cells (Extended Data Fig