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The caprylate/chromatography manufacturing process was also investigated for its capacity to decrease the infectivity of an experimental agent of transmissible spongiform encephalopathy (TSE), considered as a model for the variant Creutzfeldt-Jakob disease (vCJD), and Creutzfeldt-Jakob disease (CJD) agents.(1) These studies provide reasonable assurance that low levels of vCJD/CJD agent infectivity, if present in the starting material, would be removed by the caprylate/chromatography manufacturing process

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In contrast, in PBS-treated Tbx1 +/ versus WT brains, we identified only 3 DEGs as detailed in the previous section (Fig S4D, Table S2)

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Functional enrichment revealed associations with autophagy ( p = 1.1E-7), lipid metabolism ( p = 3.0E-6), apoptosis ( p = 3.0E-5), and stress response ( p = 8.6E-5) (Fig

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