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Specifies the full suite of in vitro tests spray content uniformity, droplet size distribution, spray pattern, plume geometry, drug particle size and the statistical framework (Population Bioequivalence, PBE analysis) for demonstrating equivalence

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10.1210/jc.2003-031274

Pathophysiology A deficiency in thiamine leads to decreased activity of thiamine-dependent enzymes that triggers a sequence of metabolic events leading to energy compromise

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