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Atopy and allergic diseases (e.g., asthma, allergic rhinitis, atopic dermatitis) were initially suggested to be negatively associated with the risk of RA, an observation that was hypothesized to be related to the predominance of Th2-dependent pathways, as opposed to a Th1 phenotype in RA (176)

Inflammation, oxidative stress, Ca 2+ dysregulation, and hypoxia can induce cellular endoplasmic reticulum stress (ERS) by overloading the ERs protein folding mechanism ( Some studies have found that ferroptosis and ERS share a common pathway, especially in tumor diseases, and disease trends can be altered by controlling the ERS or ferroptosis pathway ( 2 Ferroptosis in RA With the study of RA disease mechanisms, it has been found that the aberrant activation of RA-FLSs, destruction of articular cartilage, overactivation of immune cells, and sustained expression of inflammatory factors are associated with ferroptosis

Soc Dev 3(2):108124

Groschel A

Hyperpigmentation happens when small areas of skin make too much melanin, forming age spots, melasma, or postinflammatory marks

"Clinical effectiveness and cost-utility of photodynamic therapy for wet age-related macular degeneration: a systematic review and economic evaluation"