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However, it is noteworthy that the mechanical preparation process can induce oxidation of LMs, significantly degrading their key properties such as fluidity and thermal/electrical conductivity [61,74]

The excess fluid from the hopper overflows back into the pit

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Therefore, a possible mechanism proposed by the authors is that the activation of the farnesoid X receptor (FXR) by exendin-4 stimulates the expression of FGF15 in the small intestine and inhibits the expression of cytochrome P450 family 7 subfamily A member 1 (Cyp7a1) in the liver through fibroblast growth factor receptor 4 (FGFR4), thereby reducing fecal bile acid excretion and liver bile acid synthesis [75]

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Ketimine hydrolysis: Finally, the ketimine is hydrolyzed to form PMP and oxaloacetate